Welcome to the website of Biological Optomechanics Division

Cells are the basic entities of biological systems. They have particular physical properties, which enable them to navigate their 3D physical environment and fulfill their biological functions. We investigate these physical – mechanical and optical – properties of living cells and tissues using novel photonics and biophysical tools to test their biological importance. Our ultimate goal is the transfer of our findings to medical application in the fields of improved diagnosis of diseases and novel approaches in regenerative medicine.

Diluting of a blood sample.

How a corona infection changes blood cells in the long run

Using real-time deformability cytometry, researchers at the Max-Planck-Zentrum für Physik und Medizin in Erlangen were able to show for the first...

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Horizon Award for Leonhard Möckl

The British Royal Society of Chemistry has awarded a research team for their work on the protective sugar coat of cells, which included the scientist...

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Ministerpräsident Markus Söder und MPZPM-Sprecher Vahid Sandoghdar präsentieren die Zeitkapsel, die mit Gegenständen aus der Forschung gefüllt ist.

„Ecosystem for Ideas and Creativity”: Laying of the foundation stone for the new Max-Planck-Zentrum für Physik und Medizin

Construction phase of the innovative, interdisciplinary research institute in Erlangen begins. Minister-President and Minister of Economic Affairs...

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Cell Mechanics

Mechanical properties of cells are very often connected to their state and function. They can thus serve as an intrinsic biophysical marker of cell state transitions, such as metastasis of cancer cells, activation of leukocytes, or progression through the cell cycle. Read More...


Cells actively sense and respond to a variety of mechanical signals — a process known as mechanosensing. Mechanical cues provided by the extracellular environment can modulate a wide spectrum of cellular events, including cell proliferation, differentiation and protein production. Read More...

Tissue Mechanics

Cells define and largely form their surrounding tissues and, in return, receive biochemical and physical cues from them. We are working on resolving this interdependence by quantifying these tissue mechanical properties, correlating them with biological function, investigating their origin and ultimately controlling them. Read More...


Biophotonics describes the interaction of light with cells and tissues. We are interested in the interaction between light and tissues which is governed by the optical properties of cells. Read More...

Rapid computational cell-rotation around arbitrary axes in 3D with multi-core fiber

Jiawei Sun, Nektarios Koukourakis, Jochen Guck, Jürgen W. Czarske

Biomedical Optics Express 12(6) 3423-3437 (2021) | Journal | PDF

Quantitative imaging of Caenorhabditis elegans dauer larvae during cryptobiotic transition using optical diffraction tomography

Kyoohyun Kim, Vamshidhar Gade, Teymuras V. Kurzchalia, Jochen Guck

bioRxiv:10.1101/2021.04.26.441445 (2021) Preprint | PDF

Portable Optical Coherence Elastography System With Flexible and Phase Stable Common Path Optical Fiber Probe

Asha Parmar, Gargi Sharma, Shivani Sharma, Kanwarpal Singh

IEEE Access 9 56041-56048 (2021) | Journal | PDF


For all general inquiries, please contact us at:

Guck Division
Max Planck Institute for the Science of Light
Staudtstr. 2
D-91058 Erlangen, Germany


Tel: +49-9131-7133-501
Fax: +49-9131-7133-990

The Max Planck Institute is located right next to the Science Campus of the Friedrich-Alexander-University Erlangen-Nuremberg, on its northern edge. See the information page on how to find us.

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