Cells are the basic entities of biological systems. They have particular physical properties, which enable them to navigate their 3D physical environment and fulfill their biological functions. We investigate these physical – mechanical and optical – properties of living cells and tissues using novel photonics and biophysical tools to test their biological importance. Our ultimate goal is the transfer of our findings to medical application in the fields of improved diagnosis of diseases and novel approaches in regenerative medicine.
The construction work for the new Max-Planck-Zentrum für Physik und Medizin (MPZPM) will start: The construction site at the Schwabachanlage in...
By combining imaging of deformed cells and artificial intelligence, researchers at the Max Planck Institute for the Science of Light and the...
Cells actively sense and respond to a variety of mechanical signals — a process known as mechanosensing. Mechanical cues provided by the extracellular environment can modulate a wide spectrum of cellular events, including cell proliferation, differentiation and protein production. Read More...
Cells define and largely form their surrounding tissues and, in return, receive biochemical and physical cues from them. We are working on resolving this interdependence by quantifying these tissue mechanical properties, correlating them with biological function, investigating their origin and ultimately controlling them. Read More...
Polyacrylamide Bead Sensors for in vivo Quantification of Cell-Scale Stress in Zebrafish Development
Scientific Reports 9(1) 17031 1-14 (2019) | Journal
CASP1 variants influence subcellular caspase-1 localization, pyroptosome formation, pro-inflammatory cell death and macrophage deformability
Clinical Immunology 208 108232 (2019) | Journal
Cell Mechanics Based Computational Classification of Red Blood Cells Via Unsupervised Machine Intelligence Applied to Morpho-Rheological Markers
IEEE/ACM Transactions on Computational Biology and Bioinformatics (2019) | Journal
Mechanical changes of peripheral nerve tissue microenvironment and their structural basis during development
APL Bioengineering 3(3) 036107 (2019) | Journal
Some thoughts on the future of cell mechanics
Biophysical Review 11(15) 667-670 (2019) | Journal
3D Microenvironment Stiffness Regulates Tumor Spheroid Growth and Mechanics via p21 and ROCK
Advanced Biosystems 3(9) 1900128 (2019) | Journal
Effects of rigosertib on the osteo-hematopoietic niche in myelodysplastic syndromes
Annals of Hematology 98(9) 2063-2072 (2019) | Journal
Controlling distinct signaling states in cultured cancer cells provides a new platform for drug discovery
FASEB JOURNAL 33(8) 9235-9249 (2019) | Journal
High-Throughput Microfluidic Characterization of Erythrocyte Shapes and Mechanical Variability
Biophysical Journal 117(1) 14-24 (2019) | Journal
Analysis of biomechanical properties of hematopoietic stem and progenitor cells with Real-Time Deformability Cytometry
Methods in Molecular Biology 2017 135-148 (2019) | Book Chapter
Real-time deformability cytometry reveals sequential contraction and expansion during neutrophil priming
JOURNAL OF LEUKOCYTE BIOLOGY 105(6 SI) 1143-1153 (2019) | Journal
The relationship between metastatic potential and in vitro mechanical properties of osteosarcoma cells
MOLECULAR BIOLOGY OF THE CELL 30(7 SI) 887-898 (2019) | Journal
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