Cells are the basic entities of biological systems. They have particular physical properties, which enable them to navigate their 3D physical environment and fulfill their biological functions. We investigate these physical – mechanical and optical – properties of living cells and tissues using novel photonics and biophysical tools to test their biological importance. Our ultimate goal is the transfer of our findings to medical application in the fields of improved diagnosis of diseases and novel approaches in regenerative medicine.
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Cells actively sense and respond to a variety of mechanical signals — a process known as mechanosensing. Mechanical cues provided by the extracellular environment can modulate a wide spectrum of cellular events, including cell proliferation, differentiation and protein production. Read More...
Cells define and largely form their surrounding tissues and, in return, receive biochemical and physical cues from them. We are working on resolving this interdependence by quantifying these tissue mechanical properties, correlating them with biological function, investigating their origin and ultimately controlling them. Read More...
Mechanical changes of peripheral nerve tissue microenvironment and their structural basis during development
APL Bioengineering 3(3) 036107 036107-1-036107-12 (2019) | Journal
Controlling distinct signaling states in cultured cancer cells provides a new platform for drug discovery
FASEB JOURNAL 33(8) 9235-9249 (2019) | Journal
High-Throughput Microfluidic Characterization of Erythrocyte Shapes and Mechanical Variability
BIOPHYSICAL JOURNAL 117(1) 14-24 (2019) | Journal
Real-time deformability cytometry reveals sequential contraction and expansion during neutrophil priming
JOURNAL OF LEUKOCYTE BIOLOGY 105(6 SI) 1143-1153 (2019) | Journal
Spheroid Culture of Mesenchymal Stromal Cells Results in Morphorheological Properties Appropriate for Improved Microcirculation
ADVANCED SCIENCE 6(8) 1802104 (2019) | Journal
The relationship between metastatic potential and in vitro mechanical properties of osteosarcoma cells
MOLECULAR BIOLOGY OF THE CELL 30(7 SI) 887-898 (2019) | Journal
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