Alberto Lombardini,
Vasyl Mytskaniuk,
Siddharth Sivankutty,
Esben Ravn Andresen,
Xueqin Chen,
Jérôme Wenger,
Marc Fabert,
Nicolas Y. Joly,
Frédéric Louradour, et al.
Coherent Raman scattering microscopy is a fast, label-free, and chemically specific imaging technique that shows high potential for future in vivo optical histology. However, the imaging depth in tissues is limited to the sub-millimeter range because of absorption and scattering. Realization of coherent Raman imaging using a fiber endoscope system is a crucial step towards imaging deep inside living tissues and providing information that is inaccessible with current microscopy tools. Until now, the development of coherent Raman endoscopy has been hampered by several issues, mainly related to the fiber delivery of the excitation pulses and signal collection. Here, we present a flexible, compact, coherent Raman, and multimodal nonlinear endoscope (4.2 mm outer diameter, 71 mm rigid length) based on a resonantly scanned hollow-core Kagomé lattice double-clad fiber. The fiber design enables distortion-less, background-free delivery of femtosecond excitation pulses and back-collection of nonlinear signals through the same fiber. Sub-micrometer spatial resolution over a large field of view is obtained by combination of a miniature objective lens with a silica microsphere lens inserted into the fiber core. We demonstrate high-resolution, high-contrast coherent anti-Stokes Raman scattering, and second harmonic generation endoscopic imaging of biological tissues over a field of view of 320 µm at a rate of 0.8 frames per second. These results pave the way for intraoperative label-free imaging applied to real-time histopathology diagnosis and surgery guidance.
Dispersion tuning in sub-micron tapers for third-harmonic and photon triplet generation
Jonas Hammer,
Andrea Cavanna,
Riccardo Pennetta,
Maria Chekhova,
Philip St. J. Russell,
Nicolas Joly
Precise control of the dispersion landscape is of crucial importance if optical fibers are to be successfully used for the generation of three-photon states of light—the inverse of third-harmonic generation (THG). Here we report gas-tuning of intermodal phase-matched THG in sub-micron-diameter tapered optical fiber. By adjusting the pressure of the surrounding argon gas up to 50 bars, intermodally phase-matched third-harmonic light can be generated for pump wavelengths within a 15 nm range around 1.38 μm. We also measure the infrared fluorescence generated in the fiber when pumped in the visible and estimate that the accidental coincidence rate in this signal is lower than the predicted detection rate of photon triplets
Scientific career
Since 2021: Head of the microstructured optical fibres independent research group at the Max-Planck Institute for the Science of Light in Erlangen, Germany
Since 2009: Associate professor at the Univ. of Erlangen-Nuremberg in Germany
2005 – 2008: Maître de conférences at the Univ. of Lille in France
Education background
2012: Habilitation at the Ecole Normale Supérieure of Cachan (France) Title: Supercontinuum generation using pulses propagating in photonic crystal fibres, Defended in July. 10th 2012. Thesis adviser: Prof. Dr. Joseph Zyss.
2002-2005: Post-doctoral fellow at the University of Bath (UK) in the group of Prof. Philip Russell
1999-2002: PhD with honors (“Félicitations du jury”) at the laboratory of Physics of Lasers, Atoms, and Molecules (PhLAM) at the University of Lille (France) Title: Instabilities in pulsed mode-locked lasers: techniques for observation and control Defended on Sept. 23rd 2002. Thesis adviser: Prof. Dr. Serge Bielawski.
Awards & appointments
Since 2023: Advisor of the Erlangen Optica Student Chapter
Since 2021: Scientific coordinator of the Internation Max Planck School for the Physics of Light (IMPRS-PL)
Since 2020: Senior member of Optical Society of America (OSA)
Since 2019: Fellow of the Max Planck School of Photonics (MPSP) and member of the selection committee
Since 2016: Fellow of the Max Planck Center for Extreme and Quantum Photonics, Ottawa, Canada
1999: MENRT scholarship from the French ministry of Research to perform his doctoral degree at the University of Lille from 1999 to 2002
1998: Awarded a CIME scholarship from AUF (Agence universitaire de la Francophonie) to perform his Master study at Laval University (Québec) in 1998
Professional activities
2024: Member of the Technical Program Committee for the SPIE Photonics Europe in Strasbourg
Since 2022: Associate Editor of Opt. Express
2017: General chair of the 1st Sino-German symposium on fiber photonics for light-matter interaction in Shanghai, China
2017 – 2018: Member of the Technical Program Committee for SPIE UV and higher energy photonic
2013 – 2017: Member of Technical Program Committee for CLEO US (OSA)
2015: co-Chair of the 2nd Siegman International School of Laser (OSA)
Since 2015: Member of the Technical Program Committee for WSOF (OSA) in Hong-Kong (2015), Limasol in Cypris (2017), Adelaide in Australia (2022), and in Prague in Czech Republic (2025)
Since 20214: Member of the Student Commission of the internation Master of Advanced Optics and Technologies (MAOT)
2013: Topical session at PIERS (Progress in Electromagnetics Research Symposium) in Stockholm
2011: International conference on Nonlinear optics and complexity in photonic crystal fibers and nanostructures in Erice, in Sicily
2011: 14th International SAOT workshop on Fiber laser, sensors and materials at Reicheschwand, Germany
Since 2009: External expert for the evaluation of proposals from ANR (National agency of research in France), the Polish Society of Science, DFG (National agency of research in Germany) and ERC (European Research Council)
Since 2009: Supervisor of 13 PhD students, 2 post-docs, 14 MSc students
Ongoing projects
DFG project JO 1090/8-3 – OrbitFlySens [FAU] Orbiting flying particle sensor (with Bernhard Schmauß, FAU) – 2025-2028
BayFrance FK-34-2024 [FAU] Real-time detection of Terahertz signals using ultrashort lasers Mobility allowance – collaboration with University of Lille - 2025
BayFrance FK-35-2024 [FAU] Exploring chiral fibers for new-type of polarization-resolved endoscopy Mobility allowance – collaboration with University of Marseille – 2025
DFG project JO 1090/3-2 – Photon Triplets [FAU] Generation of photon triplets via three-photon parametric down-conversion (with Maria Chekhova) – 2024-2027
QuNet beta [MPL] 2021-2026
Max-Planck-School of Photonics (MPSP) [FAU] 2019-2025
DFG project JO 1090/6-1 -Twin Beams [FAU] Fiber source of entangled photons with giant tunable frequency separation (with Maria Chekhova) - 2021-2024
DFG project JO 1090/4-1 – Rydbergatoms in photonic crystal fibres [FAU] (with Robert Löw, University of Stuttgart) - 2019-2023
BayFrance FK-29-2018 [FAU] Frequency conversion of single-photon quantum sources using gas-filled hollow-core photonic crystal fibres Mobility allowance – collaboration with LKB, Ens Paris, France - 2018
DFG project JO 1090/3-1 – Photon Triplets [FAU] Generation of photon triplets via three-photon parametric down-conversion (with Maria Chekhova) – 2017-2020
BayFrance FK-38-2013 [FAU] Dynamical instabilities in photonic crystal fiber ring cavities synchronously pumped by femtosecond pulses Mobility allowance – collaboration with University of Lille, France - 2013-2014
