Dr. David Albrecht

  • Postdoctoral Fellow
  • Room: A.3.236
  • Telephone: +49 9131 7133348
  • E-mail

I investigate viral membranes and host interactions with high spatiotemporal resolution optical microscopy. Advanced optical microscopy methods have the advantage of live imaging capability in combination with molecular specific labeling. My aim is to further our understanding of virus infection mechanisms and how cellular processes are exploited specifically by viruses.

Measuring concentration of nanoparticles in polydisperse mixtures using interferometric nanoparticle tracking analysis (iNTA)

Anna Kashkanova, David Albrecht, Michelle Kueppers, Martin Blessing, Vahid Sandoghdar

www.biorxiv.org/content/10.1101/2024.01.09.574819v1 (2024)

Confocal Interferometric Scattering Microscopy Reveals 3D Nanoscopic Structure and Dynamics in Live Cells

Michelle Küppers, David Albrecht, Anna D. Kashkanova, Jennifer Lühr, Vahid Sandoghdar

Nature Communications 14 1962 (2023) | Journal

  • The vaccinia virus chondroitin sulfate binding protein drives host membrane curvature to facilitate fusion
    L. Pokorny, J. J. Burden, D. Albrecht, R. Bamford, K. E. Leigh, P. Sridhar, T. J. Knowles, Y. Modis and J. Mercer 
    bioRxiv preprint. doi: 10.1101/2022.03.10.483741 (2022)


  • Poxviruses package viral redox proteins in lateral bodies and modulate the host oxidative response
    S. R. Bidgood, K. Novy, A. Collopy, D. Albrecht, M. Krause, J. J. Burden, B. Wollscheid and J. Mercer
    PLoS Pathogens. doi: 10.1371/journal.ppat.1010614 (2022)


  • Modulation of Early Host Innate Immune Response by an Avipox Vaccine Virus’ Lateral Body Protein
    E. S. Giotis, S. M. Laidlaw, S. R. Bidgood, D. Albrecht, J. J. Burden, R. C. Robey, J. Mercer and M. a. Skinner
    Biomedicines. doi: 10.3390/biomedicines8120634 (2020)


  • Modulation of Early Host Innate Immune Response by an Avipox Vaccine Virus’ Lateral Body Protein
    E. S. Giotis, S. M. Laidlaw, S. R. Bidgood, D. Albrecht, J. J. Burden, R. C. Robey, J. Mercer and M. a. Skinner
    Biomedicines. doi: 10.3390/biomedicines8120634 (2020)


  • Spectrally red-shifted fluorescent fiducial markers for optimal drift correction in localization microscopy
    Balinovic, D. Albrecht and U. Endesfelder
    Journal of Physics D: Applied Physics. doi: 10.1088/1361-6463/ab0862 (2019)


  • Nanoscale polarization of the entry fusion complex of vaccinia virus drives efficient fusion
    R. D. M. Gray, D. Albrecht, C. Beerli, M. Huttunen, G. H. Cohen, I. J. White, J. J. Burden, R. Henriques and J. Mercer
    Nature Microbiology. doi: 10.1038/s41564-019-0488-4 (2019)


  • Fix your membrane receptor imaging: Actin cytoskeleton and CD4 membrane organization disruption by chemical fixation
    P. M. Pereira, D. Albrecht, S. Culley, C. Jacobs, M. Marsh, J. Mercer and R. Henriques
    Frontiers in Immunology. doi: 10.3389/fimmu.2019.00675


  • Quantitative mapping and minimization of super-resolution optical imaging artifacts
    S. Culley, D. Albrecht, C. Jacobs, P. M. Pereira, C. Leterrier, J. Mercer and R. Henriques
    Nature Methods. doi: 10.1038/nmeth.4605 (2018)


  • Revealing Compartmentalized Diffusion in Living Cells with Interferometric Scattering Microscopy
    G. de Wit, D. Albrecht, H. Ewers and P. Kukura
    Biophysical Journal. doi: 10.1016/j.bpj.2018.05.007


  • Nanoscopic compartmentalization of membrane protein motion at the axon initial segment
    D. Albrecht, C. M. Winterflood, M. Sadeghi, T. Tschager, F. Noé and H. Ewers
    The Journal of Cell Biology. doi: 10.1083/jcb.201603108 (2016)


  • Regulated endosomal trafficking of Diacylglycerol lipase alpha (DAGLα) generates distinct cellular pools; implications for endocannabinoid signaling
    Y. Zhou, F. V. Howell, O. O. Glebov, D. Albrecht, G. Williams and P. Doherty
    Molecular and Cellular Neuroscience. doi: 10.1016/j.mcn.2016.08.011 (2016)


  • Dual color single particle tracking via nanobodies
    D. Albrecht, C. M. Winterflood and H. Ewers
    Methods and Applications in Fluorescence. doi: 10.1088/2050-6120/3/2/024001 (2015)


  • Single-molecule microscopy of molecules tagged with GFP or RFP derivatives in mammalian cells using nanobody binders
    E. Platonova, C. M. Winterflood, A. Junemann, D. Albrecht, J. Faix and H. Ewers
    Methods. doi: 10.1016/j.ymeth.2015.06.018 (2015)


  • Tetraspanin-3 is an organizer of the multi-subunit Nogo-A signaling complex
    N. K. Thiede-Stan, B. Tews, D. Albrecht, Z. Ristic, H. Ewers and M. E. Schwab
    Journal of Cell Science. doi: 10.1242/jcs.167981 (2015)


  • Dual-Color 3D Superresolution Microscopy by Combined Spectral-Demixing and Biplane Imaging
    M. Winterflood, E. Platonova, D. Albrecht and H. Ewers
    Biophysical Journal. doi: 10.1016/j.bpj.2015.05.026 (2015)


  • Spatial segregation of polarity factors into distinct cortical clusters is required for cell polarity control
    J. Dodgson, A. Chessel, M. Yamamoto, F. Vaggi, S. Cox, E. Rosten, D. Albrecht, M. Geymonat, A. Csikasz-Nagy, M. Sato and R. E. Carazo-Salas
    Nature Communications. doi: 10.1038/ncomms2813 (2013)


  • Small delay, big waves: a minimal delayed negative feedback model captures Escherichia coli single cell SOS kinetics
    L. Hilbert, D. Albrecht and M. C. Mackey
    Mol. BioSyst. doi: 10.1039/c1mb05122a (2011)

David Albrecht studied biochemistry at Hanover University (BSc) and ETH Zurich (MSc) as an undergraduate student. He continued at ETH Zurich for his PhD thesis on 'The axon initial segment diffusion barrier at the nanoscopic level' in the group of Dr Helge Ewers. In 2016 he joined Dr Jason Mercer and Dr Ricardo Henriques at University College London as a postdoc to work on virus-host interactions, funded by a Marie Sklodowska-Curie fellowship. David joined the group of Dr Vahid Sandoghdar at the Max Planck Institute for the Science of Light (MPL) in Erlangen in 2019 as a postdoc to continue working with viruses.

MPL Shop

The World of Light to Touch and Wear.

Shop now!

MPL Research Centers and Schools