Welcome to the website of Biological Optomechanics Division

Cells are the basic entities of biological systems. They have particular physical properties, which enable them to navigate their 3D physical environment and fulfill their biological functions. We investigate these physical – mechanical and optical – properties of living cells and tissues using novel photonics and biophysical tools to test their biological importance. Our ultimate goal is the transfer of our findings to medical application in the fields of improved diagnosis of diseases and novel approaches in regenerative medicine.


Diagnosis and therapy of ME/CFS: What can we learn from Long Covid?

Objectively measurable parallels between Long Covid and ME/CFS: Bavarian health minister Klaus Holetschek and chair of the Bavarian health committee…

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A look back at the Long Night of Science

As part of the largest science festival in the region, MPL also opened its doors to the general public. More than 1,000 interested people visited the…

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Laboratory Animal Day - Zebrafish at MPL

The 24th of April is World Day for Laboratory Animals and we would like to take this opportunity to introduce the zebrafish Danio rerio, which makes…

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Get all Research Information here.

Cell Mechanics

Mechanical properties of cells are very often connected to their state and function. They can thus serve as an intrinsic biophysical marker of cell state transitions, such as metastasis of cancer cells, activation of leukocytes, or progression through the cell cycle. Read More...

Mechanosensing

Cells actively sense and respond to a variety of mechanical signals — a process known as mechanosensing. Mechanical cues provided by the extracellular environment can modulate a wide spectrum of cellular events, including cell proliferation, differentiation and protein production. Read More...

Tissue Mechanics

Cells define and largely form their surrounding tissues and, in return, receive biochemical and physical cues from them. We are working on resolving this interdependence by quantifying these tissue mechanical properties, correlating them with biological function, investigating their origin and ultimately controlling them. Read More...

Biophotonics

Biophotonics describes the interaction of light with cells and tissues. We are interested in the interaction between light and tissues which is governed by the optical properties of cells. Read More...

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Amoeboid-like migration ensures correct horizontal cell layer formation in the developing vertebrate retina

Rana Amini, Archit Bhatnagar, Raimund Schlüßler, Stephanie Möllmert, Jochen Guck, Caren Norden

eLife 11 e76408 (2022) | Journal | PDF


mRNA Subtype of Cancer-Associated Fibroblasts Significantly Affects Key Characteristics of Head and Neck Cancer Cells

Barbora Peltanová, Hana Holcová Polanská, Martina Raudenská, Jan Balvan, Jiri Navrátil, Tomás Vicar, Jaromir Gumulec, Barbora Cechová, Martin Kräter, et al.

Cancers / Molecular Diversity Preservation International (MDPI) 14(9) 2286 (2022) | Journal | PDF


Depressive disorders are associated with increased peripheral blood cell deformability: a cross-sectional case-control study (Mood-Morph)

Andreas Walther, Anne Mackens-Kiani, Julian Eder, Maik Herbig, Christoph Herold, Clemens Kirschbaum, Jochen Guck, Lucas Wittwer, Katja Beesdo-Baum, et al.

Translational Psychiatry 12 150 (2022) | Journal | PDF



Contact

For all general inquiries, please contact us at:

Guck Division
Max Planck Institute for the Science of Light
Staudtstr. 2
D-91058 Erlangen, Germany

guck-office@mpl.mpg.de

Tel: +49-9131-7133-501
Fax: +49-9131-7133-990

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