Dr. Hisham Mazal

  • Postdoctoral Fellow
  • Room: A.3.226
  • Telephone: +49 9131 7133343
  • E-mail

My main research goal is to develop state-of-the-art single-particle cryogenic super-resolution fluorescence microscopy to uncover the intricate structures of soluble and membrane proteins in their native environments.

Additionally, our aim is to establish a streamlined workflow for freeze-preserved specimens enabling correlative structural biology studies using the two powerful microscopy approaches of cryogenic super-resolution light and electron microscopy.

Deciphering a hexameric protein complex with Angstrom optical resolution

Hisham Mazal, Franz Wieser, Vahid Sandoghdar

eLife 11 e76308 (2022) | Journal


Self-supervised machine learning pushes the sensitivity limit in label-free detection of single proteins below 10 kDa

Mahyar Dahmardeh, Houman Mirzaalian Dastjerdi, Hisham Mazal, Harald Köstler, Vahid Sandoghdar

Nature Methods 20 442-447 (2023) | Journal


Insights into protein structure using cryogenic light microscopy

Hisham Mazal, Franz Wieser, Vahid Sandoghdar

Biochemical Society Transactions | Journal


Hisham Mazal studied Biotechnology Engineering (BSc) at ORT Braude Academic College of Engineering (Israel) from 2010 to 2013 and Chemical and Biological Physics (MSc) at Weizmann Institute of Science (Israel) from 2013 to 2015 as an undergraduate student. From 2016 to 2020 he continued at Weizmann Institute for his PhD thesis on “Single-molecule protein dynamics: From ligand binding effects on folding to function-related motions” and as a postdoc. In June 2020 Hisham Mazal joined the group of Prof. Vahid Sandoghdar at MPL as a postdoc.

MPL Research Centers and Schools