Welcome to the website of Biological Optomechanics Division

Cells are the basic entities of biological systems. They have particular physical properties, which enable them to navigate their 3D physical environment and fulfill their biological functions. We investigate these physical – mechanical and optical – properties of living cells and tissues using novel photonics and biophysical tools to test their biological importance. Our ultimate goal is the transfer of our findings to medical application in the fields of improved diagnosis of diseases and novel approaches in regenerative medicine.


Laboratory Animal Day - Zebrafish at MPL

The 24th of April is World Day for Laboratory Animals and we would like to take this opportunity to introduce the zebrafish Danio rerio, which makes…

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Director Jochen Guck honored by the Saxon Academy of Sciences and Humanities

Jochen Guck received the Wilhelm Ostwald Medal of the Saxon Academy of Sciences and Humanities in Leipzig, which is usually awarded annually to a…

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"My fingers are itching, I would love to start next week." Time capsule embedded at the Max Planck Center for Physics and Medicine

The next step in the construction of a special large-scale project has been taken: after the foundation stone was laid in 2021, employees of the…

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Get all Research Information here.

Cell Mechanics

Mechanical properties of cells are very often connected to their state and function. They can thus serve as an intrinsic biophysical marker of cell state transitions, such as metastasis of cancer cells, activation of leukocytes, or progression through the cell cycle. Read More...

Mechanosensing

Cells actively sense and respond to a variety of mechanical signals — a process known as mechanosensing. Mechanical cues provided by the extracellular environment can modulate a wide spectrum of cellular events, including cell proliferation, differentiation and protein production. Read More...

Tissue Mechanics

Cells define and largely form their surrounding tissues and, in return, receive biochemical and physical cues from them. We are working on resolving this interdependence by quantifying these tissue mechanical properties, correlating them with biological function, investigating their origin and ultimately controlling them. Read More...

Biophotonics

Biophotonics describes the interaction of light with cells and tissues. We are interested in the interaction between light and tissues which is governed by the optical properties of cells. Read More...

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Changes in Blood Cell Deformability in Chorea-Acanthocytosis and Effects of Treatment With Dasatinib or Lithium

Felix Reichel, Martin Kräter, Kevin Peikert, Hannes Glaß, Philipp Rosendahl, Maik Herbig, Alejandro Rivera Prieto, Alexander Kihm, Giel Bosman, et al.

Frontiers in Physiology 13 852946 (2022) | Journal | PDF


An explicit model to extract viscoelastic properties of cells from AFM force-indentation curves

Shada Abuhattum Hofemeier, Dominic Mokbel, Paul Müller, Despina Soteriou, Jochen Guck, Sebastian Aland

iScience 25(4) 104016 (2022) | Journal | PDF


Epithelial RAC1-dependent cytoskeleton dynamics controls cell mechanics, cell shedding and barrier integrity in intestinal inflammation

Luz del Carmen Martínez-Sánchez, Phuong Anh Ngo, Rashmita Pradhan, Lukas-Sebastian Becker, David Boehringer, Despina Soteriou, Markéta Kubánková, Christine Schweitzer, Tatjana Koch, et al.

Gut 1-20 (2022) | Journal | PDF



Contact

For all general inquiries, please contact us at:

Guck Division
Max Planck Institute for the Science of Light
Staudtstr. 2
D-91058 Erlangen, Germany

guck-office@mpl.mpg.de

Tel: +49-9131-7133-501
Fax: +49-9131-7133-990

The Max Planck Institute is located right next to the Science Campus of the Friedrich-Alexander-University Erlangen-Nuremberg, on its northern edge. See the information page on how to find us.

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Current issue: Newsletter No 16 - February 2021

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